Your joints first-aid supplement.
• 240 capsules / 500 mg
• Pure Pharmaceutical Grade
Glucosamine Sulfate (sodium free, 65 mg calium) 500 mg
Dosage: 1 capsule 3 times daily
Glucosamine is an aminosugar found throughout the body. It is synthesized by the glucosamine synthetase, combining glucose and the aminoacid glutamine.
Glucosamine is an essential componant of many macromolecules (glycoprotein, glycosaminoglycan, proteoglycan). These macromolecules play vital roles: in the interstitium, they form the basis for the matrix (collagen and proteoglycan); in the mucus membrane, they are found in the basal membrane, the glycocalyx and the mucus itself; in the joints, they form the tendons, ligaments, cartilage and synovial fluid.
The aminosugars being synthesized by the body, the demand sometimes exceeds the supply in the event of strains, wounds and various aggressions. In many diseases, a lack of glycoproteins or other substances based on aminosugars has been found. Osteoarthritis and inflammatory bowel disease are but some of those diseases.
An hypothesis has been made that supplementation of glucosamine sulfate might stimulate the synthesis of the missing glycoproteins. Since the early 80's, research is confirming this hypothesis with the improvement of the symptoms of patients treated with glucosamine sulfate. Studies have compared glucosamine sulfate with ibuprofen and indomethacin in osteoarthritis. The anti-inflammatory drugs relieved the symptoms faster but had a negative long term effect on the cartilage and the evolution of the disease. Glucosamine sulfate brought relief after only two weeks of treatment. After eight weeks, the relief lasted even after the cessation of treatment.
Glucosamine sulfate is a prodrug quickly absorbed (90%), metabolised by the liver, strongly linked to plasmatic proteins and well distributed to action sites where it is used for the synthesis of glycoproteins, glycosaminoglycans and proteoglycans. Only 28% is excreted in the urine. Since glucosamine sulfate is not metabolised as a sugar, it should not interfere with diabetis.
Glucosamine sulfate stimulates the synthesis of glycolysed substances by bypassing the enzyme glucosamine synthetase.
Dosage and side effects:
The suggested dosage is 50mg/kg in divided doses with meals. The side effects are minor and similar to placebo. There has been cases of diarrhea and rash.
Glucosamine sulfate is indicated in joint problems such as osteoarthritis and arthrosis. It has also been studied in the inflammatory bowel disease (Crohn's disease, ulcerative colitis) with good results. In theory, glucosamine sulfate can help anywhere glycoprotein synthesis may be at fault: mucus membrane, interstitium matrix, etc.
The onset of action of the glucosamine sulfate is from 2 to 8 weeks since it operates by stimulating the endogenous synthesis of the missing macromolecules.
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